| Back Slack Reach | Berkeley, SC | 62.5 miles | SE |
| Slack Reach | Berkeley, SC | 62.5 miles | SE |
| Cowhea Reach | Charleston, SC | 63.8 miles | SE |
| Navy Yard Reach | Charleston, SC | 65.3 miles | SE |
| Duck Island Channel | Charleston, SC | 66.3 miles | SE |
| New Cut | Charleston, SC | 67.4 miles | SE |
| Daniel Island Reach | Berkeley, SC | 67.8 miles | SE |
| Drum Island Reach | Charleston, SC | 67.8 miles | SE |
| Custom House Reach | Charleston, SC | 68.4 miles | SE |
| Town Creek Upper Reach | Charleston, SC | 68.8 miles | SE |
| Town Creek | Charleston, SC | 68.9 miles | SE |
| Elliott Cut | Charleston, SC | 69.2 miles | SE |
| Hog Island Reach | Charleston, SC | 69.7 miles | SE |
| Town Creek Lower Reach | Charleston, SC | 69.7 miles | SE |
| Watts Cut | Charleston, SC | 70.3 miles | SE |
| Horse Reach | Charleston, SC | 70.7 miles | SE |
| Shutes Reach | Charleston, SC | 71.2 miles | SE |
| Bull Cut | Colleton, SC | 71.4 miles | SE |
| Folly Reach | Charleston, SC | 71.5 miles | SE |
| Schooner Channel | Beaufort, SC | 71.7 miles | SE |
| Hog Island Channel | Charleston, SC | 71.9 miles | SE |
| Rebellion Reach | Charleston, SC | 72.1 miles | SE |
| Folly Island Channel | Charleston, SC | 72.2 miles | SE |
| South Channel | Charleston, SC | 72.7 miles | SE |
| Sullivans Island Narrows | Charleston, SC | 74 miles | SE |
| Santee Pass | Charleston, SC | 74.9 miles | SE |
| Meeting Reach | Charleston, SC | 75 miles | SE |
| Bull Narrows | Charleston, SC | 75.4 miles | SE |
| Fenwick Cut | Colleton, SC | 75.5 miles | SE |
| Ashepoo Coosaw Cutoff | Colleton, SC | 76.1 miles | SE |
| Cutoff Reach | Charleston, SC | 76.3 miles | SE |
| Mosquito Camp Cutoff | Screven, GA | 76.3 miles | SW |
| Mathews Cut | Charleston, SC | 77 miles | SE |
| Island Cut | Charleston, SC | 78 miles | SE |
| Cornhouse Reach | Hampton, SC | 78.3 miles | SW |
| Cornhouse Reach | Screven, GA | 78.6 miles | SW |
| Parrot Creek | Beaufort, SC | 78.6 miles | SE |
| Otter Creek | Colleton, SC | 79.3 miles | SE |
| Little Cornhouse Reach | Hampton, SC | 79.5 miles | SW |
| Little Cornhouse Reach | Screven, GA | 79.5 miles | SW |
| Wildcat Cut | Screven, GA | 80.9 miles | SW |
| Factory Creek | Beaufort, SC | 81.7 miles | SW |
| Doe Point Creek | Beaufort, SC | 81.9 miles | SE |
| Hudson Ferry Reach | Hampton, SC | 82.4 miles | SW |
| Hudson Ferry Reach | Hampton, SC | 82.6 miles | SW |
| Western Channel | Georgetown, SC | 82.6 miles | SE |
| Four Mile Reach | Edgefield, SC | 82.7 miles | SW |
| Four Mile Reach | Columbia, GA | 82.7 miles | SW |
| Slack Reach | Charleston, SC | 82.9 miles | SE |
| Goldwires Reach | Hampton, SC | 83 miles | SW |
|