| McNeil Airport | Calhoun, SC | 3.9 miles | SW |
| Saint Matthews Airport | Calhoun, SC | 6.1 miles | NW |
| Regional Medical Center of Orangeburg and Calhoun County Heliport | Orangeburg, SC | 12.3 miles | SW |
| Santee Golf Air Strip | Orangeburg, SC | 13.5 miles | SE |
| Orangeburg Municipal Airport | Orangeburg, SC | 16.5 miles | SW |
| Alans Airport | Calhoun, SC | 18.4 miles | NW |
| Russell Airport | Orangeburg, SC | 20.2 miles | SE |
| Creech Aviation Facility Airport | Sumter, SC | 20.6 miles | NE |
| Monoghan Auxiliary Airfield (historical) | Sumter, SC | 22.4 miles | NE |
| Santee Cooper Regional Airport | Clarendon, SC | 24.7 miles | SE |
| Clarendon Memorial Hospital Heliport | Clarendon, SC | 25 miles | NE |
| Holly Hill Airport | Orangeburg, SC | 25.6 miles | SE |
| North Air Force Auxiliary Field | Orangeburg, SC | 25.8 miles | NW |
| Lexington County Airport | Lexington, SC | 29.1 miles | NW |
| Saint George Municipal Airport | Dorchester, SC | 29.7 miles | SE |
| Bamberg Hospital Heliport | Bamberg, SC | 30.8 miles | SW |
| Sumter Municipal Airport | Sumter, SC | 30.9 miles | NE |
| Crosswinds-Wilson Private Airport | Berkeley, SC | 32.2 miles | SE |
| Columbia Owens Downtown Airport | Richland, SC | 32.4 miles | NW |
| Owens Field Airport | Richland, SC | 32.7 miles | NW |
| Bamberg County Airport | Bamberg, SC | 34.6 miles | SW |
| Dabbs Airport | Sumter, SC | 35.2 miles | NE |
| Providence Hospital Heliport | Richland, SC | 35.3 miles | NW |
| Darden Airport | Lexington, SC | 35.3 miles | NW |
| Palmetto Center Heliport | Richland, SC | 35.6 miles | NW |
| Columbia Metropolitan Airport | Lexington, SC | 35.9 miles | NW |
| El Porvenir Airpark | Kershaw, SC | 36.2 miles | NE |
| Richland Memorial Hospital Heliport | Richland, SC | 36.8 miles | NW |
| Falcon Airport | Lexington, SC | 37.1 miles | NW |
| Corporate Airport | Lexington, SC | 37.3 miles | NW |
| Lexington Medical Center Heliport | Lexington, SC | 38.1 miles | NW |
| Byrd Field | Clarendon, SC | 41.2 miles | NE |
| Ehrhardt Airport | Bamberg, SC | 42 miles | SW |
| Eagles Nest-Fairview Airpark | Lexington, SC | 42.9 miles | NW |
| Dorchester County Airport | Dorchester, SC | 43.1 miles | SE |
| Lane Airport (historical) | Williamsburg, SC | 44 miles | SE |
| Tallon Field | Lee, SC | 44.8 miles | NE |
| Berkeley County Airport | Berkeley, SC | 45.4 miles | SE |
| Williamsburg County Airport | Williamsburg, SC | 45.5 miles | NE |
| Woodward Field | Kershaw, SC | 46.7 miles | NE |
| Gilbert International Airport | Lexington, SC | 46.9 miles | NW |
| Walterboro Municipal Airport | Colleton, SC | 47.8 miles | SW |
| Broxton Bridge Plantation Airport | Colleton, SC | 48.2 miles | SW |
| Lee County Airport | Lee, SC | 49.4 miles | NE |
| Barnwell County Airport | Barnwell, SC | 49.8 miles | SW |
| Lamar Airport | Darlington, SC | 50.1 miles | NE |
| Lake City Municipal Airport | Florence, SC | 52.6 miles | NE |
| Phillips Airstrip | Allendale, SC | 52.9 miles | SW |
| Shealy Airport | Lexington, SC | 54.4 miles | NW |
| McKay Airport | Florence, SC | 54.5 miles | NE |
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