| Narrows of the Yadkin | Stanly, NC | 83.7 miles | NE |
| Hell Gate | Georgetown, SC | 94.4 miles | SE |
| Four Mile Reach | Columbia, GA | 97.9 miles | SW |
| Four Mile Reach | Edgefield, SC | 97.9 miles | SW |
| Middleton Cut | Georgetown, SC | 98.5 miles | SE |
| Slack Reach | Berkeley, SC | 100.5 miles | SE |
| Back Slack Reach | Berkeley, SC | 100.7 miles | SE |
| Western Channel | Georgetown, SC | 103.4 miles | SE |
| Yahany Inlet (historical) | Georgetown, SC | 104.3 miles | SE |
| Cowhea Reach | Charleston, SC | 104.6 miles | SE |
| Navy Yard Reach | Charleston, SC | 104.8 miles | SE |
| Mathews Cut | Charleston, SC | 105.4 miles | SE |
| Island Cut | Charleston, SC | 106.1 miles | SE |
| Drum Island Reach | Charleston, SC | 107.1 miles | SE |
| Bull Narrows | Charleston, SC | 109.6 miles | SE |
| Slue Channel (historical) | Georgetown, SC | 109.6 miles | SE |
| Santee Pass | Charleston, SC | 110.1 miles | SE |
| South Santee Inlet | Georgetown, SC | 110.2 miles | SE |
| North Santee Inlet | Georgetown, SC | 110.6 miles | SE |
| Slack Reach | Charleston, SC | 110.7 miles | SE |
| Bottle Channel | Georgetown, SC | 110.9 miles | SE |
| Winyah Bay Entrance | Georgetown, SC | 111.6 miles | SE |
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