| Hell Gate | Georgetown, SC | 40 miles | SE |
| Middleton Cut | Georgetown, SC | 42.7 miles | SE |
| Western Channel | Georgetown, SC | 48.3 miles | SE |
| Yahany Inlet (historical) | Georgetown, SC | 48.5 miles | SE |
| Mathews Cut | Charleston, SC | 54 miles | SE |
| Island Cut | Charleston, SC | 54.3 miles | SE |
| Slue Channel (historical) | Georgetown, SC | 54.4 miles | SE |
| Bottle Channel | Georgetown, SC | 55.7 miles | SE |
| North Santee Inlet | Georgetown, SC | 56.2 miles | SE |
| South Santee Inlet | Georgetown, SC | 56.2 miles | SE |
| Winyah Bay Entrance | Georgetown, SC | 56.3 miles | SE |
| Slack Reach | Charleston, SC | 58.4 miles | SE |
| Slack Reach | Berkeley, SC | 60 miles | SW |
| Back Slack Reach | Berkeley, SC | 60.5 miles | SW |
| Bull Narrows | Charleston, SC | 62.8 miles | SE |
| Santee Pass | Charleston, SC | 64.3 miles | SE |
| Navy Yard Reach | Charleston, SC | 65.9 miles | SW |
| Drum Island Reach | Charleston, SC | 67.3 miles | SW |
| Daniel Island Reach | Berkeley, SC | 67.8 miles | SW |
| Cowhea Reach | Charleston, SC | 67.9 miles | SW |
| Custom House Reach | Charleston, SC | 68 miles | SW |
| Duck Island Channel | Charleston, SC | 68.2 miles | SW |
| Town Creek Upper Reach | Charleston, SC | 69 miles | SW |
| Town Creek | Charleston, SC | 69.2 miles | SW |
| Meeting Reach | Charleston, SC | 69.3 miles | SE |
| Hog Island Reach | Charleston, SC | 69.5 miles | SW |
| Town Creek Lower Reach | Charleston, SC | 70 miles | SW |
| Hog Island Channel | Charleston, SC | 70.6 miles | SW |
| Horse Reach | Charleston, SC | 70.7 miles | SW |
| Shutes Reach | Charleston, SC | 70.9 miles | SW |
| Folly Reach | Charleston, SC | 71 miles | SW |
| Sullivans Island Narrows | Charleston, SC | 71.2 miles | SW |
| Rebellion Reach | Charleston, SC | 71.3 miles | SW |
| Folly Island Channel | Charleston, SC | 71.6 miles | SW |
| Intracoastal Waterway | Brunswick, NC | 72.2 miles | NE |
| Elliott Cut | Charleston, SC | 72.3 miles | SW |
| South Channel | Charleston, SC | 72.4 miles | SW |
| Little River Inlet | Brunswick, NC | 72.5 miles | NE |
| East River | Brunswick, NC | 72.7 miles | NE |
| Mad Inlet | Brunswick, NC | 73.3 miles | NE |
| The Big Narrows | Brunswick, NC | 74.7 miles | NE |
| Tubbs Inlet | Brunswick, NC | 75.7 miles | NE |
| Eastern Channel | Brunswick, NC | 77 miles | NE |
| New Cut | Charleston, SC | 77.6 miles | SW |
| Cutoff Reach | Charleston, SC | 79.5 miles | SW |
| Shallotte Inlet | Brunswick, NC | 81.9 miles | NE |
| Boone Channel | Brunswick, NC | 82.7 miles | NE |
| Watts Cut | Charleston, SC | 88.5 miles | SW |
| Lockwoods Folly Inlet | Brunswick, NC | 90.4 miles | NE |
| Eastern Channel | Brunswick, NC | 91 miles | NE |
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