| Kingstree Swamp Canal | Williamsburg, SC | 1.9 miles | NW |
| High Hill Drainage Canal | Florence, SC | 10.1 miles | NE |
| Polk Swamp Canal | Florence, SC | 26.6 miles | NE |
| Atkins Drainage Canal | Lee, SC | 26.8 miles | NW |
| Santee Canal | Berkeley, SC | 31.2 miles | SW |
| Bulltown Ditch | Berkeley, SC | 33.1 miles | SW |
| Catfish Canal | Marion, SC | 34.4 miles | NE |
| Boyd Canal | Horry, SC | 37 miles | NE |
| Jeffries Ditch | Darlington, SC | 37.7 miles | NW |
| Moultrie Canal (historical) | Berkeley, SC | 37.8 miles | SW |
| Ophir Canal (historical) | Berkeley, SC | 38.9 miles | SW |
| Tailrace Canal | Berkeley, SC | 41.3 miles | SW |
| Old Santee Canal | Berkeley, SC | 41.7 miles | SW |
| Fox Swamp Canal | Dillon, SC | 48.1 miles | NE |
| Hester Canal | Berkeley, SC | 49.7 miles | SE |
| Estherville Minim Creek Canal | Georgetown, SC | 50.2 miles | SE |
| Fourmile Creek Canal | Georgetown, SC | 52.5 miles | SE |
| Rockfish Canal | Georgetown, SC | 52.6 miles | SE |
| Mosquito Creek Canal | Georgetown, SC | 53.8 miles | SE |
| Jumping Gully | Kershaw, SC | 54.6 miles | NW |
| Gilles Ditch | Kershaw, SC | 56.1 miles | NW |
| Wateree Canal (historical) | Kershaw, SC | 64.8 miles | NW |
| Sevenmile Viaduct | Charleston, SC | 65.3 miles | SW |
| Stevens Canal | Robeson, NC | 66 miles | NE |
| Fivemile Viaduct | Charleston, SC | 66.8 miles | SW |
| Piney Island Canal | Robeson, NC | 67.9 miles | NE |
| Big Branch Canal | Robeson, NC | 68.4 miles | NE |
| Willoughby Canal | Robeson, NC | 68.9 miles | NE |
| Big Swamp Canal | Robeson, NC | 69.5 miles | NE |
| Gum Swamp Canal | Robeson, NC | 69.8 miles | NE |
| Peniten Canal | Columbus, NC | 70.9 miles | NE |
| Gum Branch Canal | Robeson, NC | 71.3 miles | NE |
| Columbia Canal | Richland, SC | 73.9 miles | NW |
| Isaac Jennings Canal | Orangeburg, SC | 74.6 miles | SW |
| Bryant Swamp Canal | Bladen, NC | 75.6 miles | NE |
| Main Line Ditch | Richland, SC | 76 miles | NW |
| Cove Canal | Columbus, NC | 79.5 miles | NE |
| Marsh Canal | Bladen, NC | 79.8 miles | NE |
| Allen Pocket Canal | Bladen, NC | 82.3 miles | NE |
| Harlem Canal | Columbus, NC | 85.7 miles | NE |
| Lateral Canal D | Columbus, NC | 87 miles | NE |
| Lateral Canal E | Columbus, NC | 87.9 miles | NE |
| Line Canal | Columbus, NC | 88.2 miles | NE |
| Lateral Canal F | Columbus, NC | 88.8 miles | NE |
| Matthews Canal | Colleton, SC | 88.8 miles | SW |
| Lateral Canal G | Columbus, NC | 89.6 miles | NE |
| Lateral Canal H | Columbus, NC | 90.2 miles | NE |
| Strauss Canal | Columbus, NC | 90.3 miles | NE |
| Landsford Canal | Chester, SC | 91.3 miles | NW |
| Hair Canal | Cumberland, NC | 95.4 miles | NE |
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