| Pen Branch | Orangeburg, SC | 2.4 miles | SW |
| Betty Branch | Orangeburg, SC | 2.7 miles | SW |
| Brier Creek | Bamberg, SC | 3.4 miles | SW |
| North Fork Edisto River | Orangeburg, SC | 4.1 miles | NW |
| South Fork Edisto River | Bamberg, SC | 4.1 miles | NW |
| Mill Branch | Orangeburg, SC | 5.1 miles | NW |
| Sandy Run | Orangeburg, SC | 5.3 miles | NE |
| Murray Branch | Orangeburg, SC | 6.1 miles | SE |
| Bush Branch | Dorchester, SC | 6.6 miles | SE |
| Cooper Swamp | Orangeburg, SC | 6.8 miles | NW |
| Staley Branch | Orangeburg, SC | 7 miles | NW |
| Box Branch | Dorchester, SC | 7.4 miles | SE |
| Mill Branch | Dorchester, SC | 7.5 miles | SE |
| Dry Swamp | Orangeburg, SC | 8.4 miles | NW |
| Buck Branch | Orangeburg, SC | 8.8 miles | NE |
| Big Branch | Dorchester, SC | 9.4 miles | SE |
| Steedley Branch | Colleton, SC | 10.1 miles | SW |
| Cattle Creek | Dorchester, SC | 10.4 miles | SE |
| Lemon Creek | Bamberg, SC | 10.4 miles | SW |
| Drawdy Branch | Bamberg, SC | 10.4 miles | SW |
| Hurricane Branch | Bamberg, SC | 10.4 miles | SW |
| Buck Branch | Orangeburg, SC | 10.7 miles | NE |
| Whirlwind Creek | Orangeburg, SC | 10.7 miles | NW |
| Colt Branch | Bamberg, SC | 10.7 miles | SW |
| Anderson Branch | Orangeburg, SC | 10.9 miles | NW |
| Bear Branch | Dorchester, SC | 11.7 miles | SE |
| Mill Branch | Orangeburg, SC | 11.7 miles | NE |
| Snell Branch | Orangeburg, SC | 11.7 miles | NE |
| Crum Branch | Orangeburg, SC | 12.4 miles | NE |
| Long Branch | Bamberg, SC | 12.7 miles | SW |
| Snake Swamp | Orangeburg, SC | 12.8 miles | NW |
| Smith Drain | Bamberg, SC | 12.9 miles | SW |
| Brickhouse Branch | Colleton, SC | 13 miles | SE |
| Sam Branch | Orangeburg, SC | 13.3 miles | NW |
| McMillian Branch | Bamberg, SC | 13.4 miles | SW |
| Halfmoon Branch | Bamberg, SC | 13.5 miles | NW |
| Wadboo Branch | Dorchester, SC | 13.5 miles | SE |
| Patrick Branch | Orangeburg, SC | 13.8 miles | NE |
| Roberts Swamp | Orangeburg, SC | 14 miles | NW |
| Bear Branch | Colleton, SC | 14.2 miles | SE |
| Colston Branch | Bamberg, SC | 14.3 miles | SW |
| Grapevine Branch | Bamberg, SC | 14.7 miles | NW |
| Cowtail Creek | Dorchester, SC | 14.7 miles | SE |
| Indian Camp Branch | Bamberg, SC | 15.4 miles | SW |
| Mill Branch | Orangeburg, SC | 15.7 miles | NE |
| Cow Castle Creek | Orangeburg, SC | 15.9 miles | NE |
| Sucksand Branch | Orangeburg, SC | 16.4 miles | NW |
| Bush Branch | Orangeburg, SC | 16.4 miles | NE |
| Hog Branch | Colleton, SC | 16.8 miles | SW |
| Little Bull Creek | Orangeburg, SC | 17 miles | NE |
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