| Cowhea Reach | Charleston, SC | 51.9 miles | SE |
| Back Slack Reach | Berkeley, SC | 52.9 miles | SE |
| New Cut | Charleston, SC | 53 miles | SE |
| Slack Reach | Berkeley, SC | 53.2 miles | SE |
| Schooner Channel | Beaufort, SC | 53.7 miles | SE |
| Watts Cut | Charleston, SC | 53.7 miles | SE |
| Bull Cut | Colleton, SC | 54.4 miles | SE |
| Navy Yard Reach | Charleston, SC | 54.4 miles | SE |
| Duck Island Channel | Charleston, SC | 54.8 miles | SE |
| Daniel Island Reach | Berkeley, SC | 56.8 miles | SE |
| Drum Island Reach | Charleston, SC | 56.9 miles | SE |
| Elliott Cut | Charleston, SC | 57 miles | SE |
| Town Creek Upper Reach | Charleston, SC | 57.5 miles | SE |
| Custom House Reach | Charleston, SC | 57.5 miles | SE |
| Town Creek | Charleston, SC | 57.6 miles | SE |
| Town Creek Lower Reach | Charleston, SC | 58.4 miles | SE |
| Fenwick Cut | Colleton, SC | 58.5 miles | SE |
| Hog Island Reach | Charleston, SC | 58.6 miles | SE |
| Ashepoo Coosaw Cutoff | Colleton, SC | 58.7 miles | SE |
| Horse Reach | Charleston, SC | 59.4 miles | SE |
| Shutes Reach | Charleston, SC | 59.8 miles | SE |
| Folly Reach | Charleston, SC | 60.3 miles | SE |
| Mosquito Camp Cutoff | Screven, GA | 60.6 miles | SW |
| Folly Island Channel | Charleston, SC | 60.8 miles | SE |
| Hog Island Channel | Charleston, SC | 60.8 miles | SE |
| Rebellion Reach | Charleston, SC | 60.9 miles | SE |
| Parrot Creek | Beaufort, SC | 60.9 miles | SE |
| South Channel | Charleston, SC | 61.3 miles | SE |
| Cornhouse Reach | Hampton, SC | 62.2 miles | SW |
| Otter Creek | Colleton, SC | 62.3 miles | SE |
| Cornhouse Reach | Screven, GA | 62.4 miles | SW |
| Little Cornhouse Reach | Screven, GA | 63.2 miles | SW |
| Sullivans Island Narrows | Charleston, SC | 63.2 miles | SE |
| Little Cornhouse Reach | Hampton, SC | 63.2 miles | SW |
| Cutoff Reach | Charleston, SC | 63.4 miles | SE |
| Factory Creek | Beaufort, SC | 63.6 miles | SE |
| Doe Point Creek | Beaufort, SC | 64.1 miles | SE |
| Wildcat Cut | Screven, GA | 64.7 miles | SW |
| Meeting Reach | Charleston, SC | 65.1 miles | SE |
| Hudson Ferry Reach | Hampton, SC | 65.9 miles | SW |
| Goldwires Reach | Effingham, GA | 66 miles | SW |
| Hudson Ferry Reach | Hampton, SC | 66 miles | SW |
| Goldwires Reach | Hampton, SC | 66 miles | SW |
| Santee Pass | Charleston, SC | 66.8 miles | SE |
| Bull Narrows | Charleston, SC | 67.8 miles | SE |
| Port Royal Reach | Beaufort, SC | 67.8 miles | SE |
| Cat Island Creek | Beaufort, SC | 68.2 miles | SE |
| Cat Island Reach | Beaufort, SC | 68.9 miles | SE |
| Archers Creek | Beaufort, SC | 68.9 miles | SW |
| Cowen Reach | Beaufort, SC | 70.6 miles | SE |
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