| Isaac Jennings Canal | Orangeburg, SC | 16.6 miles | SW |
| Bulltown Ditch | Berkeley, SC | 33.5 miles | NE |
| Santee Canal | Berkeley, SC | 34.2 miles | NE |
| Ophir Canal (historical) | Berkeley, SC | 34.7 miles | SE |
| Moultrie Canal (historical) | Berkeley, SC | 37.8 miles | SE |
| Old Santee Canal | Berkeley, SC | 41.9 miles | SE |
| Tailrace Canal | Berkeley, SC | 41.9 miles | SE |
| Columbia Canal | Richland, SC | 51.2 miles | NW |
| Matthews Canal | Colleton, SC | 51.7 miles | SE |
| Sevenmile Viaduct | Charleston, SC | 51.8 miles | SE |
| Fivemile Viaduct | Charleston, SC | 54.3 miles | SE |
| Main Line Ditch | Richland, SC | 54.4 miles | NW |
| Hester Canal | Berkeley, SC | 54.7 miles | SE |
| Jumping Gully | Kershaw, SC | 57.1 miles | NE |
| Gilles Ditch | Kershaw, SC | 57.2 miles | NE |
| Atkins Drainage Canal | Lee, SC | 59.1 miles | NE |
| Kingstree Swamp Canal | Williamsburg, SC | 59.3 miles | NE |
| Switzerland Canal | Jasper, SC | 66.4 miles | SW |
| High Hill Drainage Canal | Florence, SC | 69 miles | NE |
| Wateree Canal (historical) | Kershaw, SC | 69.6 miles | NW |
| Beaverdam Ditch | Richmond, GA | 73.9 miles | NW |
| Phinizy Ditch | Richmond, GA | 74.3 miles | NW |
| Jeffries Ditch | Darlington, SC | 75.7 miles | NE |
| Augusta Canal | Richmond, GA | 76.5 miles | NW |
| Fourmile Creek Canal | Georgetown, SC | 80.5 miles | SE |
| Polk Swamp Canal | Florence, SC | 81.7 miles | NE |
| Estherville Minim Creek Canal | Georgetown, SC | 82.3 miles | SE |
| Lucknow Canal | Jasper, SC | 84.2 miles | SW |
| Taylor Canal | Jasper, SC | 85.1 miles | SW |
| Rockfish Canal | Georgetown, SC | 85.2 miles | SE |
| Mosquito Creek Canal | Georgetown, SC | 85.9 miles | SE |
| Murray Hill Canal | Jasper, SC | 87.2 miles | SW |
| Clydesdale Canal | Jasper, SC | 88.1 miles | SW |
| Shubra Canal | Jasper, SC | 88.1 miles | SW |
| Pipe Makers Canal | Chatham, GA | 89.9 miles | SW |
| Springfield Canal | Chatham, GA | 91.4 miles | SW |
| Hardin Canal | Chatham, GA | 92.5 miles | SW |
| Savannah and Ogeechee Canal | Chatham, GA | 92.6 miles | SW |
| Placentia Canal | Chatham, GA | 92.8 miles | SW |
| Catfish Canal | Marion, SC | 93.1 miles | NE |
| Boyd Canal | Horry, SC | 94.3 miles | NE |
| Landsford Canal | Chester, SC | 99.5 miles | NW |
| Peachtree Canal | Chatham, GA | 102.4 miles | SW |
| Valambrosia Canal | Chatham, GA | 102.4 miles | SW |
| Southfield Canal | Chatham, GA | 102.5 miles | SW |
| Walker Canal | Chatham, GA | 102.8 miles | SW |
| New Hope Canal | Chatham, GA | 103.4 miles | SW |
| Five Docks Canal | Chatham, GA | 103.4 miles | SW |
| Elbow Canal | Chatham, GA | 103.5 miles | SW |
| Red Dock Canal | Chatham, GA | 103.5 miles | SW |
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