| Slack Reach | Berkeley, SC | 26.6 miles | SE |
| Back Slack Reach | Berkeley, SC | 26.9 miles | SE |
| Navy Yard Reach | Charleston, SC | 31.9 miles | SE |
| Cowhea Reach | Charleston, SC | 33.3 miles | SW |
| Drum Island Reach | Charleston, SC | 33.7 miles | SE |
| Duck Island Channel | Charleston, SC | 34 miles | SE |
| Daniel Island Reach | Berkeley, SC | 34.1 miles | SE |
| Custom House Reach | Charleston, SC | 34.4 miles | SE |
| Mathews Cut | Charleston, SC | 34.5 miles | SE |
| Bull Narrows | Charleston, SC | 34.9 miles | SE |
| Santee Pass | Charleston, SC | 35.3 miles | SE |
| Town Creek Upper Reach | Charleston, SC | 35.3 miles | SE |
| Town Creek | Charleston, SC | 35.4 miles | SE |
| Island Cut | Charleston, SC | 35.5 miles | SE |
| Hog Island Reach | Charleston, SC | 35.9 miles | SE |
| Town Creek Lower Reach | Charleston, SC | 36.3 miles | SE |
| Horse Reach | Charleston, SC | 37.1 miles | SE |
| Shutes Reach | Charleston, SC | 37.5 miles | SE |
| Hog Island Channel | Charleston, SC | 37.5 miles | SE |
| Folly Reach | Charleston, SC | 37.7 miles | SE |
| Meeting Reach | Charleston, SC | 37.9 miles | SE |
| Elliott Cut | Charleston, SC | 38 miles | SW |
| Rebellion Reach | Charleston, SC | 38 miles | SE |
| Folly Island Channel | Charleston, SC | 38.3 miles | SE |
| Sullivans Island Narrows | Charleston, SC | 38.7 miles | SE |
| South Channel | Charleston, SC | 39.1 miles | SE |
| Slack Reach | Charleston, SC | 40.4 miles | SE |
| Western Channel | Georgetown, SC | 42 miles | SE |
| New Cut | Charleston, SC | 42.6 miles | SW |
| South Santee Inlet | Georgetown, SC | 43.4 miles | SE |
| North Santee Inlet | Georgetown, SC | 44.9 miles | SE |
| Middleton Cut | Georgetown, SC | 45.5 miles | NE |
| Cutoff Reach | Charleston, SC | 45.5 miles | SE |
| Slue Channel (historical) | Georgetown, SC | 47.5 miles | SE |
| Yahany Inlet (historical) | Georgetown, SC | 48.5 miles | NE |
| Bottle Channel | Georgetown, SC | 48.5 miles | SE |
| Winyah Bay Entrance | Georgetown, SC | 49.3 miles | SE |
| Watts Cut | Charleston, SC | 53.5 miles | SW |
| Hell Gate | Georgetown, SC | 54.2 miles | NE |
| Bull Cut | Colleton, SC | 56.7 miles | SW |
| Fenwick Cut | Colleton, SC | 59.5 miles | SW |
| Ashepoo Coosaw Cutoff | Colleton, SC | 62 miles | SW |
| Otter Creek | Colleton, SC | 62.7 miles | SW |
| Schooner Channel | Beaufort, SC | 63.7 miles | SW |
| Parrot Creek | Beaufort, SC | 66.7 miles | SW |
| Doe Point Creek | Beaufort, SC | 70.1 miles | SW |
| Factory Creek | Beaufort, SC | 72.4 miles | SW |
| Old House Creek | Beaufort, SC | 74.5 miles | SW |
| Scott Creek | Beaufort, SC | 76.2 miles | SW |
| Cat Island Creek | Beaufort, SC | 76.9 miles | SW |
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