| Moultrie Canal (historical) | Berkeley, SC | 3.4 miles | SW |
| Ophir Canal (historical) | Berkeley, SC | 6.1 miles | SW |
| Tailrace Canal | Berkeley, SC | 6.6 miles | SE |
| Old Santee Canal | Berkeley, SC | 7 miles | SE |
| Bulltown Ditch | Berkeley, SC | 9 miles | NW |
| Santee Canal | Berkeley, SC | 10 miles | NW |
| Hester Canal | Berkeley, SC | 19.6 miles | SE |
| Sevenmile Viaduct | Charleston, SC | 30.8 miles | SW |
| Fivemile Viaduct | Charleston, SC | 32.7 miles | SE |
| Kingstree Swamp Canal | Williamsburg, SC | 35.9 miles | NE |
| Fourmile Creek Canal | Georgetown, SC | 40.5 miles | SE |
| Estherville Minim Creek Canal | Georgetown, SC | 42 miles | SE |
| Rockfish Canal | Georgetown, SC | 44.9 miles | SE |
| High Hill Drainage Canal | Florence, SC | 45.1 miles | NE |
| Mosquito Creek Canal | Georgetown, SC | 45.6 miles | SE |
| Atkins Drainage Canal | Lee, SC | 52.8 miles | NW |
| Matthews Canal | Colleton, SC | 54.1 miles | SW |
| Isaac Jennings Canal | Orangeburg, SC | 57.1 miles | NW |
| Boyd Canal | Horry, SC | 59.9 miles | NE |
| Polk Swamp Canal | Florence, SC | 61.8 miles | NE |
| Catfish Canal | Marion, SC | 68.2 miles | NE |
| Jeffries Ditch | Darlington, SC | 68.5 miles | NW |
| Jumping Gully | Kershaw, SC | 70.1 miles | NW |
| Gilles Ditch | Kershaw, SC | 71.1 miles | NW |
| Columbia Canal | Richland, SC | 78.6 miles | NW |
| Main Line Ditch | Richland, SC | 81.6 miles | NW |
| Fox Swamp Canal | Dillon, SC | 82.7 miles | NE |
| Wateree Canal (historical) | Kershaw, SC | 83 miles | NW |
| Switzerland Canal | Jasper, SC | 86.2 miles | SW |
| Peniten Canal | Columbus, NC | 96.8 miles | NE |
| Stevens Canal | Robeson, NC | 98.3 miles | NE |
| Piney Island Canal | Robeson, NC | 100.2 miles | NE |
| Willoughby Canal | Robeson, NC | 101.1 miles | NE |
| Big Branch Canal | Robeson, NC | 101.1 miles | NE |
| Big Swamp Canal | Robeson, NC | 101.5 miles | NE |
| Gum Swamp Canal | Robeson, NC | 101.9 miles | NE |
| Lucknow Canal | Jasper, SC | 102 miles | SW |
| Taylor Canal | Jasper, SC | 102.6 miles | SW |
| Murray Hill Canal | Jasper, SC | 103.6 miles | SW |
| Shubra Canal | Jasper, SC | 104.3 miles | SW |
| Clydesdale Canal | Jasper, SC | 104.5 miles | SW |
| Gum Branch Canal | Robeson, NC | 104.9 miles | NE |
| Cove Canal | Columbus, NC | 106.9 miles | NE |
| Bryant Swamp Canal | Bladen, NC | 107.5 miles | NE |
| Placentia Canal | Chatham, GA | 107.8 miles | SW |
| Springfield Canal | Chatham, GA | 107.9 miles | SW |
| Pipe Makers Canal | Chatham, GA | 108.2 miles | SW |
| Savannah and Ogeechee Canal | Chatham, GA | 111.5 miles | SW |
| Harlem Canal | Columbus, NC | 111.7 miles | NE |
| Hardin Canal | Chatham, GA | 112 miles | SW |
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